Impact of combined consumption of fish oil and probiotics on the serum metabolome in pregnant women with overweight or obesity.

ABSTRACT:

Background

If a pregnant woman is overweight, this can evoke metabolic alterations that may have health consequences for both mother and child.

Methods

Pregnant women with overweight/obesity (n = 358) received fish oil+placebo, probiotics+placebo, fish oil+probiotics or placebo+placebo from early pregnancy onwards. The serum metabolome was analysed from fasting samples with a targeted NMR-approach in early and late pregnancy. GDM was diagnosed by OGTT.

Findings

The intervention changed the metabolic profile of the women, but the effect was influenced by their GDM status. In women without GDM, the changes in nine lipids (FDR<0.05) in the fish oil+placebo-group differed when compared to the placebo+placebo-group. The combination of fish oil and probiotics induced change

SUBMITTER: Mokkala K 

PROVIDER: S-EPMC8577343 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature