Immunophenotyping and Transcriptional Profiling of Human Plasmablasts in Dengue.

ABSTRACT: Plasmablasts represent a specialized class of antibody-secreting effector B cells that transiently appear in blood circulation following infection or vaccination. The expansion of these cells generally tends to be massive in patients with systemic infections such as dengue or Ebola that cause hemorrhagic fever. To gain a detailed understanding of human plasmablast responses beyond antibody expression, here, we performed immunophenotyping and RNA sequencing (RNA-seq) analysis of the plasmablasts from dengue febrile children in India. We found that plasmablasts expressed several adhesion molecules and chemokines or chemokine receptors that are involved in endothelial interactions or homing to inflamed tissues, including skin, mucosa, and intestine, and upregulated the expression of several c

SUBMITTER: Aggarwal C 

PROVIDER: S-EPMC8577383 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature