Gemcitabine radiosensitization primes irradiated malignant meningioma cells for senolytic elimination by navitoclax.

ABSTRACT:

Background

Malignant meningioma is an aggressive tumor that requires adjuvant radiotherapy after surgery, yet there has been no standard systemic therapy established so far. We recently reported that malignant meningioma cells are highly sensitive to gemcitabine; however, it remains unknown whether or how gemcitabine interacts with ionizing radiation (IR) in malignant meningioma cells.

Methods

We examined the radiosensitization effects of gemcitabine using malignant meningioma cell lines and xenografts and explored the underlying mechanisms.

Results

Gemcitabine sensitized malignant meningioma cells to IR through the induction of senescence both in vitro and in vivo. Gemcitabine augmented the intracellular production of reactive oxygen species (ROS) by IR, which, toget

SUBMITTER: Yamamoto M 

PROVIDER: S-EPMC8577526 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature