Clopidogrel treatment inhibits P2Y₂-Mediated constriction in the rabbit middle cerebral artery.

ABSTRACT: Clopidogrel is an effective purinergic 2Y₁₂ receptor (P2Y₁₂) antagonist used to prevent arterial thrombosis, but its use is associated with adverse bleeding. Clinical studies have demonstrated that clopidogrel users have an increased risk of cerebral microbleeds and intracerebral hemorrhage. Our previous studies suggest that non-platelet mechanisms mediate these adverse bleeding events; we hypothesize that clopidogrel or one of its metabolites interacts with blood vessels directly to cause bleeding. New Zealand white rabbits (1.9-2.7 kg) were treated orally with vehicle or clopidogrel (3 or 10 mg/kg) for three days. On the fourth day, the rabbits were anesthetized for blood collection and then euthanized. The brain was collected, and the middle cerebral arteries were

SUBMITTER: Kuszynski DS 

PROVIDER: S-EPMC8577565 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature