Effectiveness of portable HEPA air cleaners on reducing indoor endotoxin, PM_10, and coarse particulate matter in an agricultural cohort of children with asthma: A randomized intervention trial.

ABSTRACT: We conducted a randomized trial of portable HEPA air cleaners in the homes of children age 6-12 years with asthma in the Yakima Valley, Washington. All families received asthma education while intervention families also received two HEPA cleaners (child's bedroom, living room). We collected 14-day integrated samples of endotoxin in settled dust and PM₁₀ and PM_10-2.5 in the air of the children's bedrooms at baseline and one-year follow-up, and used linear regression to compare follow-up levels, adjusting for baseline. Seventy-one families (36 HEPA, 35 control) completed the study. Baseline geometric mean (GSD) endotoxin loadings were 1565 (6.3) EU/m² and 2110 (4.9) EU/m² , respectively, in HEPA vs. control homes while PM₁₀ and PM₁₀

SUBMITTER: Riederer AM 

PROVIDER: S-EPMC8577577 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature