The Proteomic Signature of Recombinant Growth Hormone in Recreational Athletes.

ABSTRACT:

Objective

Administration of human growth hormone (hGH) is prohibited in competitive sport and its detection in an athlete's sample triggers an adverse analytical finding. However, the biological processes that are modulated by recombinant hGH are not well characterized and associated blood serum proteins may constitute new biomarkers for hGH misuse.

Methods

Thirty-five recreational athletes were enrolled in a study to investigate the time- and dose-dependent response of serum protein levels to recombinant hGH administration. Participants were randomly assigned to 4 groups, receiving 1 of 3 different doses of recombinant hGH or a placebo. Bio samples were collected at 22 time points over a period of 13 weeks, starting 4 weeks before treatment, during 3 weeks of treatment, and

SUBMITTER: Esefeld M 

PROVIDER: S-EPMC8577606 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature