Gut microbiome affects the metabolism of metronidazole in mice through regulation of hepatic cytochromes P450 expression.

ABSTRACT: Microbiome is now considered as a significant metabolic organ with an immense potential to influence overall human health. A number of diseases that are associated with pharmacotherapy interventions was linked with altered gut microbiota. Moreover, it has been reported earlier that gut microbiome modulates the fate of more than 30 commonly used drugs and, vice versa, drugs have been shown to affect the composition of the gut microbiome. The molecular mechanisms of this mutual relationship, however, remain mostly elusive. Recent studies indicate an indirect effect of the gut microbiome through its metabolites on the expression of biotransformation enzymes in the liver. The aim of this study was to analyse the effect of gut microbiome on the fate of metronidazole in the mice through modulati

SUBMITTER: Zemanova N 

PROVIDER: S-EPMC8577747 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature