Change in the central control of the bladder function of rats with focal cerebral infarction induced by photochemically-induced thrombosis.

ABSTRACT: The photochemically-induced thrombosis (photothrombosis) method can create focal cerebral infarcts anywhere in the relatively superficial layers of the cerebrum; it is easy to implement and minimally invasive. Taking advantage of this versatility, we aimed to establish a new rat model of urinary frequency with focal cerebral infarction, which was characterized by its simplicity, nonlethal nature, and high reproducibility. The prefrontal cortex and the anterior cingulate cortex, which are involved in lower urinary tract control, were targeted for focal cerebral infarction, and urinary parameters were measured by cystometrogram. Cystometric analysis indicated that micturition intervals significantly shortened in photothrombosis-treated rats compared with those in the sham operative group on

SUBMITTER: Ota Y 

PROVIDER: S-EPMC8577768 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature