Correlates of Adherence to the Dapivirine Vaginal Ring for HIV-1 Prevention.

ABSTRACT: Understanding characteristics associated with adherence to pre-exposure prophylaxis (PrEP) methods for HIV-1 prevention may assist with optimizing implementation efforts. The dapivirine vaginal ring is a novel topical PrEP delivery method. Using data from a randomized, double-blind, placebo-controlled, phase III trial of the dapivirine vaginal ring conducted in four African countries, generalized estimating equation models were used to evaluate correlates of ring adherence. Two levels of quarterly dapivirine blood plasma, and dapivirine released from returned rings defined measures of adherence for recent and cumulative use, respectively. Time on study, calendar time, primary partner knowledge that the participant was taking part in the study, and use of long-acting contraceptive methods w

SUBMITTER: Husnik MJ 

PROVIDER: S-EPMC8577988 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature