Urinary metabolomic signatures as indicators of injury severity following traumatic brain injury: A pilot study.

ABSTRACT:

Background

Analysis of fluid metabolites has the potential to provide insight into the neuropathophysiology of injury in patients with traumatic brain injury (TBI).

Objective

Using a ¹H nuclear magnetic resonance (NMR)-based quantitative metabolic profiling approach, this study determined (1) if urinary metabolites change during recovery in patients with mild to severe TBI; (2) whether changes in urinary metabolites correlate to injury severity; (3) whether biological pathway analysis reflects mechanisms that mediate neural damage/repair throughout TBI recovery.

Methods

Urine samples were collected within 7 days and at 6-months post-injury in male participants (n = 8) with mild-severe TBI. Samples were analyzed with NMR-based quantitative spectroscopy for m

SUBMITTER: Bykowski EA 

PROVIDER: S-EPMC8578034 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature