A voxel-level brain-wide association study of cortisol at 8 a.m.: Evidence from Cushing's disease.

ABSTRACT: Cortisol, the end product of the hypothalamic-pituitary-adrenal axis, regulates cognitive function and emotion processing. Cushing's disease, which is characterized by a unique excess of cortisol upon clinical diagnosis, serve as an excellent in vivo "hyperexpression" model to investigate the neurobiological mechanisms of cortisol in the human brain. Previous studies have shown the association between cortisol and functional connectivity within an a priori brain network. However, the whole-brain connectivity pattern that accompanies endogenous cortisol variation is still unclear, as are its associated genetic underpinnings. Here, using resting-state functional magnetic resonance imaging in 112 subjects (60 patients with Cushing's disease and 52 healthy subjects), we performed a voxe

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC8578035 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature