Potential structural trait markers of depression in the form of alterations in the structures of subcortical nuclei and structural covariance network properties.

ABSTRACT: It has been proposed recently that major depressive disorder (MDD) could represent an adaptation to conserve energy after the perceived loss of an investment in a vital source, such as group identity, personal assets, or relationships. Energy conserving behaviors associated with MDD may form a persistent marker in brain regions and networks involved in cognition and emotion regulation. In this study, we examined whether subcortical regions and volume-based structural covariance networks (SCNs) have state-independent alterations (trait markers). First-episode drug-naïve currently depressed (cMDD) patients (N = 131), remitted MDD (RD) patients (N = 67), and healthy controls (HCs, N = 235) underwent structural magnetic resonance imaging (MRI). Subcortical gray matter volumes (GMVs) were calcu

SUBMITTER: Xiong G 

PROVIDER: S-EPMC8578037 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature