Cross-Modality Imaging of Murine Tumor Vasculature-a Feasibility Study.

ABSTRACT: Tumor vasculature and angiogenesis play a crucial role in tumor progression. Their visualization is therefore of utmost importance to the community. In this proof-of-principle study, we have established a novel cross-modality imaging (CMI) pipeline to characterize exactly the same murine tumors across scales and penetration depths, using orthotopic models of melanoma cancer. This allowed the acquisition of a comprehensive set of vascular parameters for a single tumor. The workflow visualizes capillaries at different length scales, puts them into the context of the overall tumor vessel network and allows quantification and comparison of vessel densities and morphologies by different modalities. The workflow adds information about hypoxia and blood flow rates. The CMI approach includes well-

SUBMITTER: Zopf LM 

PROVIDER: S-EPMC8578087 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature