Outcomes associated with the use of medications for opioid use disorder during pregnancy.

ABSTRACT:

Aim

To test the effect of the duration of medication for opioid use disorder (MOUD) use during pregnancy on maternal, perinatal and neonatal outcomes.

Design

Retrospective cohort analysis of claims, encounter and pharmacy data.

Setting

Pennsylvania, USA.

Participants

We analyzed 13 320 pregnancies among 10 741 women with opioid use disorder aged 15-44 years enrolled in Pennsylvania Medicaid between 2009 and 2017.

Measurements

We examined five outcomes during pregnancy and for 12 weeks postpartum: (1) overdose, (2) postpartum MOUD continuation, (3) preterm birth (< 37 weeks gestation), (4) term low birth weight (< 2500 g at ≥ 37 weeks) and (5) neonatal abstinence syndrome (NAS). Our primary exposure was the duration (count of weeks) of any MOUD use, inclu

SUBMITTER: Krans EE 

PROVIDER: S-EPMC8578145 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature