Survey of water proton longitudinal relaxation in liver in vivo.

ABSTRACT:

Objective

To determine the variability, and preferred values, for normal liver longitudinal water proton relaxation rate R₁ in the published literature.

Methods

Values of mean R₁ and between-subject variance were obtained from literature searching. Weighted means were fitted to a heuristic and to a model.

Results

After exclusions, 116 publications (143 studies) remained, representing apparently normal liver in 3392 humans, 99 mice and 249 rats. Seventeen field strengths were included between 0.04 T and 9.4 T. Older studies tended to report higher between-subject coefficients of variation (CoV), but for studies published since 1992, the median between-subject CoV was 7.4%, and in half of those studies, measured R₁ deviated from model by

SUBMITTER: Waterton JC 

PROVIDER: S-EPMC8578172 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature