Impact of treatment duration on mortality among Veterans with opioid use disorder in the United States Veterans Health Administration.

ABSTRACT:

Background and aims

While long-term medication-assisted treatment (MAT) using methadone or buprenorphine is associated with significantly lower all-cause mortality for individuals with opioid use disorder (OUD), periods of initiating or discontinuing treatment are associated with higher mortality risks relative to stable treatment. This study aimed to identify the OUD treatment durations necessary for the elevated mortality risks during treatment transitions to be balanced by reductions in mortality while receiving treatment.

Design

Simulation model based on a compartmental model of OUD diagnosis, MAT receipt and all-cause mortality among Veterans with OUD in the United States Veterans Health Administration (VA) in 2017-2018. We simulated methadone and buprenorphine treatmen

SUBMITTER: Ching JH 

PROVIDER: S-EPMC8578188 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature