Genetic association of primary nonresponse to anti-TNFα therapy in patients with inflammatory bowel disease.

ABSTRACT:

Objectives

Primary nonresponse (PNR) to antitumor necrosis factor-α (TNFα) biologics is a serious concern in patients with inflammatory bowel disease (IBD). We aimed to identify the genetic variants associated with PNR.

Patients and methods

Patients were recruited from outpatient GI clinics and PNR was determined using both clinical and endoscopic findings. A case-control genome-wide association study was performed in 589 IBD patients and associations were replicated in an independent cohort of 293 patients. Effect of the associated variant on gene expression and TNFα secretion was assessed by cell-based assays. Pleiotropic effects were investigated by Phenome-wide association study (PheWAS).

Results

We identified rs34767465 as associated with PNR to anti-TNFα therapy

SUBMITTER: De T 

PROVIDER: S-EPMC8578201 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature