Cluster Analysis and Genotype-Phenotype Assessment of Geographic Atrophy in Age-Related Macular Degeneration: Age-Related Eye Disease Study 2 Report 25.

ABSTRACT:

Purpose

To explore whether phenotypes in geographic atrophy (GA) secondary to age-related macular degeneration can be separated into 2 or more partially distinct subtypes and if these have different genetic associations. This is important because distinct GA subtypes associated with different genetic factors might require customized therapeutic approaches.

Design

Cluster analysis of participants within a controlled clinical trial, followed by assessment of phenotype-genotype associations.

Participants

Age-Related Eye Disease Study 2 participants with incident GA during study follow-up: 598 eyes of 598 participants.

Methods

Phenotypic features from reading center grading of fundus photographs were subjected to cluster analysis, by k-means and hierarchical method

SUBMITTER: Keenan TDL 

PROVIDER: S-EPMC8578299 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature