A risk-based framework for assessing real-time lung cancer screening eligibility that incorporates life expectancy and past screening findings.

ABSTRACT:

Background

Current lung cancer risk-based screening approaches use a single risk-threshold, disregard life-expectancy, and ignore past screening findings. We address these limitations with a comprehensive analytical framework, the individualized lung cancer screening decision (ENGAGE) tool that aims to optimize lung cancer screening for US ever-smokers under dynamic risk assessment by incorporating life expectancy and past screening findings over time.

Methods

ENGAGE employs a partially observable Markov decision process framework that integrates published risk prediction and disease progression models, to dynamically assess the trade-off between the expected health benefits and harms associated with screening. ENGAGE evaluates lung cancer risk annually and provides real-tim

SUBMITTER: Toumazis I 

PROVIDER: S-EPMC8578300 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature