Genetic ancestry differences in pediatric asthma readmission are mediated by socioenvironmental factors.

ABSTRACT:

Background

Social and financial hardships, combined with disease managment and environmental factors explain approximately 80% of the observed disparity in asthma-related readmissions between Black and White children.

Objective

We sought to determine whether asthma-related readmissions differed by degree of African ancestry and the extent to which such an association would also be explained by socioenvironmental risk factors.

Methods

This study used data from a prospective cohort study of 695 Black and White children aged 1 to 16 years with an asthma-related admission. The primary outcome was a similar readmission within 12 months. Each subject's African ancestry was determined by single nucleotide polymorphisms on a continuous scale ranging from 0 to 1 (0 = no Africa

SUBMITTER: Mersha TB 

PROVIDER: S-EPMC8578303 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature