Associations of neonicotinoids with insulin and glucose homeostasis parameters in US adults: NHANES 2015-2016.

ABSTRACT: Neonicotinoids are replacement insecticides increasingly used for organophosphates, methylcarbamates, and pyrethroids. Experimental evidence suggests neonicotinoids may affect glucose metabolism and insulin secretion through pancreatic β cell dysfunction, oxidative stress, and inflammation. However, no epidemiologic study has investigated neonicotinoids as potential diabetogens. We examined associations between neonicotinoids with insulin and glucose homeostasis parameters among 1381 non-diabetic adults in the National Health and Nutrition Examination Survey (2015-2016). Urinary concentrations of acetamiprid, clothianidin, imidacloprid, N-desmethyl-acetamiprid, and 5-hydroxy-imidacloprid were quantified. Fasting plasma glucose, insulin, and hemoglobin A_1c (HbA_1c) were

SUBMITTER: Vuong AM 

PROVIDER: S-EPMC8578312 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature