Relationship between Papillomavirus vaccine, vaginal microbiome, and local cytokine response: an exploratory research.

ABSTRACT:

Introduction

The influence of vaccination on composition of the human microbiome at distinct sites has been recognized as an essential component in the development of new vaccine strategies. The HPV vaccine is widely used to prevent cervical cancer; however, the influence of HPV vaccine on the vaginal microbiota has not been previously investigated. In his study, we performed an initial characterization of the microbiome and cytokine composition in the vagina following administration of the bivalent vaccine against HPV 16/18.

Material and methods

In this exploratory study, fifteen women between 18 and 40 years received three doses of the HPV-16/18 AS04-adjuvanted vaccine (Cervarix®). Cervicovaginal samples were collected before the first dose and 30 days after the third dose

SUBMITTER: Giraldo PC 

PROVIDER: S-EPMC8578365 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature