Anti-PD-1 Checkpoint Therapy Can Promote the Function and Survival of Regulatory T Cells.

ABSTRACT: We have previously shown in a model of claudin-low breast cancer that regulatory T cells (T_regs) are increased in the tumor microenvironment (TME) and express high levels of PD-1. In mouse models and patients with triple-negative breast cancer, it is postulated that one cause for the lack of activity of anti-PD-1 therapy is the activation of PD-1-expressing T_regs in the TME. We hypothesized that the expression of PD-1 on T_regs would lead to enhanced suppressive function of T_regs and worsen antitumor immunity during PD-1 blockade. To evaluate this, we isolated T_regs from claudin-low tumors and functionally evaluated them ex vivo. We compared transcriptional profiles of T_regs isolated from tumor-bearing mice with or without an

SUBMITTER: Vick SC 

PROVIDER: S-EPMC8578393 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature