Perturbation-specific responses by two neural circuits generating similar activity patterns.

ABSTRACT: A fundamental question in neuroscience is whether neuronal circuits with variable circuit parameters that produce similar outputs respond comparably to equivalent perturbations.^1-4 Work on the pyloric rhythm of the crustacean stomatogastric ganglion (STG) showed that highly variable sets of intrinsic and synaptic conductances can generate similar circuit activity patterns.^5-9 Importantly, in response to physiologically relevant perturbations, these disparate circuit solutions can respond robustly and reliably,^10-12 but when exposed to extreme perturbations the underlying circuit parameter differences produce diverse patterns of disrupted activity.^7,12,13 In this example, the pyloric circuit is unchanged

SUBMITTER: Powell DJ 

PROVIDER: S-EPMC8578407 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature