Single nucleotide polymorphisms within HLA region are associated with the outcomes of unrelated cord blood transplantation.

ABSTRACT: Cord blood transplantation (CBT) provides a treatment scheme for hematologic diseases and leukemia in both children and adults. However, adverse reactions and transplantation-related death may still occur in patients receiving CBT even when donor and recipient have fully matched HLA in high-resolution HLA typing analysis. Single nucleotide polymorphisms (SNPs) of HLA-related and unrelated genes are known to associate with disease status of patients with unrelated stem cell transplantation. In this study, the genomic regions ranging from 500 base pairs upstream to 500 base pairs downstream of the eight SNPs that were reported as transplantation determinants by Petersdorf et al. were analyzed to evaluate whether genetic variants were associated with the survival status of patients, and the r

SUBMITTER: Chen DP 

PROVIDER: S-EPMC8578435 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature