Ethanol effects on cerebellar myelination in a postnatal mouse model of fetal alcohol spectrum disorders.

ABSTRACT: Fetal alcohol spectrum disorders (FASD) are alarmingly common, result in significant personal and societal loss, and there are no effective treatments for these disorders. Cerebellar neuropathology is common in FASD and can cause impaired cognitive and motor function. The current study evaluates the effects of ethanol on oligodendrocyte-lineage cells, as well as molecules that modulate oligodendrocyte differentiation and function in the cerebellum in a postnatal mouse model of FASD. Neonatal mice were treated with ethanol from P4-P9 (postnatal day), the cerebellum was isolated at P10, and mRNAs encoding oligodendrocyte-associated molecules were quantitated by qRT-PCR. Our studies demonstrated that ethanol significantly reduced the expression of markers for multiple stages of oligodendrocyt

SUBMITTER: Niedzwiedz-Massey VM 

PROVIDER: S-EPMC8578461 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature