Dual-Modality PET-SPECT Image-Guided Pretargeting Delivery in HER2(+) Breast Cancer Models.

ABSTRACT: Pretargeted drug delivery has been explored for decades as a promising approach in cancer therapy. An image-guided pretargeting strategy significantly enhances the intrinsic advantages of this approach since imaging the pretargeting step can be used for diagnostic purposes, while imaging of the drug delivery step can be utilized to evaluate drug distribution and assess therapeutic response. A trastuzumab (Tz)-based HER2 pretargeting component (Tz-TCO-[⁸⁹Zr-DFO]) was developed by conjugating with trans-cyclooctene (TCO) bioorthogonal click chemistry functional groups and deferoxamine (DFO) to enable radiolabeling with a ⁸⁹Zr PET tracer. The drug delivery component (HSA-DM1-Tt-[^99mTc-HyNic]) was developed by conjugating human serum albumin (HSA) with m

SUBMITTER: Hapuarachchige S 

PROVIDER: S-EPMC8578463 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature