In vitro and in silico analysis reveals antifungal activity and potential targets of curcumin on Paracoccidioides spp.

ABSTRACT: The search for new compounds with activity against Paracoccidioides, etiologic agents of Paracoccidioidomycosis (PCM), is extremely necessary due to the current scenario of the available therapeutic arsenal. Treatment is restricted to three classes of antifungals with side effects. Curcumin is a polyphenol with antifungal effects that is extracted from Curcuma longa. The present work aimed to evaluate the activity of curcumin in different species of Paracoccidioides and to evaluate the potential molecular targets of curcumin using computational strategies. In addition, interactions with classic antifungals used in the treatment of PCM were evaluated. Curcumin inhibits the growth of Paracoccidioides spp. exerting a fungicidal effect. The combination of curcumin with amphotericin B, co-trimo

SUBMITTER: Rocha OB 

PROVIDER: S-EPMC8578512 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature