Widespread attenuating changes in brain connectivity associated with the general factor of psychopathology in 9- and 10-year olds.

ABSTRACT: Convergent research identifies a general factor ("P factor") that confers transdiagnostic risk for psychopathology. Large-scale networks are key organizational units of the human brain. However, studies of altered network connectivity patterns associated with the P factor are limited, especially in early adolescence when most mental disorders are first emerging. We studied 11,875 9- and 10-year olds from the Adolescent Brain and Cognitive Development (ABCD) study, of whom 6593 had high-quality resting-state scans. Network contingency analysis was used to identify altered interconnections associated with the P factor among 16 large-scale networks. These connectivity changes were then further characterized with quadrant analysis that quantified the directionality of P factor effects in relat

SUBMITTER: Sripada C 

PROVIDER: S-EPMC8578613 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature