Mid-lateral cerebellar complex spikes encode multiple independent reward-related signals during reinforcement learning.

ABSTRACT: Although the cerebellum has been implicated in simple reward-based learning recently, the role of complex spikes (CS) and simple spikes (SS), their interaction and their relationship to complex reinforcement learning and decision making is still unclear. Here we show that in a context where a non-human primate learned to make novel visuomotor associations, classifying CS responses based on their SS properties revealed distinct cell-type specific encoding of the probability of failure after the stimulus onset and the non-human primate's decision. In a different context, CS from the same cerebellar area also responded in a cell-type and learning independent manner to the stimulus that signaled the beginning of the trial. Both types of CS signals were independent of changes in any motor kinem

SUBMITTER: Sendhilnathan N 

PROVIDER: S-EPMC8578621 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature