Photoactivated cell-killing amino-based flavylium compounds.

ABSTRACT: Photodynamic therapy (PDT) is a well-established therapeutic for the treatment of different diseases. The growing interest of this technique required the development of new photosensitizers with better photo-features. This work reports the study of the potential of five nature-inspired amino-based flavylium compounds with different structural features as photosensitizers towards topical PDT. In terms of dark cytotoxicity the five pigments were tested towards confluent skin cells in both fibroblasts and keratinocytes. In the range of concentrations tested (6.3-100 μM), keratinocytes were more prone to growth inhibition and the IC₅₀ values for 5OH4'NMe₂, 7NEt₂st4'NMe₂ and 7NEt₂4'NH₂ were determined to be 47.3 ± 0.3 μM; 91.0 ± 

SUBMITTER: Oliveira H 

PROVIDER: S-EPMC8578629 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature