An integrated computational framework to design a multi-epitopes vaccine against Mycobacterium tuberculosis.

ABSTRACT: Tuberculosis (TB) is a highly contagious disease that mostly affects the lungs and is caused by a bacterial pathogen, Mycobacterium tuberculosis. The associated mortality rate of TB is much higher compared to any other disease and the situation is more worrisome by the rapid emergence of drug resistant strains. Bacillus Calmette-Guerin (BCG) is the only licensed attenuated vaccine available for use in humans however, many countries have stopped its use as it fails to confer protective immunity. Therefore, urgent efforts are required to identify new and safe vaccine candidates that are not only provide high immune protection but also have broad spectrum applicability. Considering this, herein, I performed an extensive computational vaccine analysis to investigate 200 complete sequenced geno

SUBMITTER: Albutti A 

PROVIDER: S-EPMC8578660 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature