Serum biomarkers in severe paediatric traumatic brain injury-a narrative review.

ABSTRACT: Severe traumatic brain injury continues to present complex management and prediction challenges for the clinician. While there is some evidence that better systems of care can improve outcome, multiple multi-centre randomised controlled trials of specific therapies have consistently failed to show benefit. In addition, clinicians are challenged in attempting to accurately predict which children will recover well and which children will have severe and persisting neurocognitive deficits. Traumatic brain injury is vastly heterogeneous and so it is not surprising that one therapy or approach, when applied to a mixed cohort of children in a clinical trial setting, has yielded disappointing results. Children with severe traumatic brain injury have vastly different brain injury pathologies of wi

SUBMITTER: Ganeshalingham A 

PROVIDER: S-EPMC8578762 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature