Identification of a ferroptosis-related lncRNA signature with prognosis for Wilms tumor.

ABSTRACT:

Background

Wilms tumor (WT) is a widespread urologic tumor in children. Ferroptosis, on the other hand, is a novel form of cell death associated with tumor development. In this study, we aim to explore the predictability of ferroptosis-related biomarkers in estimating prognosis in WT patients.

Methods

To determine a link between ferroptosis-related gene expression and WT prognosis, we first collected RNA sequencing data and clinical information, involving 124 WT and 6 healthy tissue samples, from the TARGET database. Next, we screened the collected information for ferroptosis-related long non-coding RNA using Cox regression analysis, and constructed a signature model, as well as a nomogram, related to prognosis. Finally, we explored a potential link between ferroptosis-relat

SUBMITTER: Liu H 

PROVIDER: S-EPMC8578763 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature