A narrative review of skeletal muscle atrophy in critically ill children: pathogenesis and chronic sequelae.

ABSTRACT: Muscle wasting is now recognized as a growing, debilitating problem in critically ill adults, resulting in long-term deficits in function and an impaired quality of life. Ultrasonography has demonstrated decreases in skeletal muscle size during pediatric critical illness, although variations exist. However, muscle protein turnover patterns during pediatric critical illness are unclear. Understanding muscle protein turnover during critical illness is important in guiding interventions to reduce muscle wasting. The aim of this review was to explore the possible protein synthesis and breakdown patterns in pediatric critical illness. Muscle protein turnover studies in critically ill children are lacking, with the exception of those with burn injuries. Children with burn injuries demonstrate an

SUBMITTER: Ong C 

PROVIDER: S-EPMC8578782 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature