From Millimeters to Micrometers; Re-introducing Myocytes in Models of Cardiac Electrophysiology.

ABSTRACT: Computational modeling has contributed significantly to present understanding of cardiac electrophysiology including cardiac conduction, excitation-contraction coupling, and the effects and side-effects of drugs. However, the accuracy of in silico analysis of electrochemical wave dynamics in cardiac tissue is limited by the homogenization procedure (spatial averaging) intrinsic to standard continuum models of conduction. Averaged models cannot resolve the intricate dynamics in the vicinity of individual cardiomyocytes simply because the myocytes are not present in these models. Here we demonstrate how recently developed mathematical models based on representing every myocyte can significantly increase the accuracy, and thus the utility of modeling electrophysiological function and d

SUBMITTER: Jæger KH 

PROVIDER: S-EPMC8578869 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature