Derivation and Clinical Validation of a Redox-Driven Prognostic Signature for Colorectal Cancer.

ABSTRACT: Colorectal cancer (CRC), a seriously threat that endangers public health, has a striking tendency to relapse and metastasize. Redox-related signaling pathways have recently been extensively studied in cancers. However, the study and potential role of redox in CRC remain unelucidated. We developed and validated a risk model for prognosis and recurrence prediction in CRC patients via identifying gene signatures driven by redox-related signaling pathways. The redox-driven prognostic signature (RDPS) was demonstrated to be an independent risk factor for patient survival (including OS and RFS) in four public cohorts and one clinical in-house cohort. Additionally, there was an intimate association between the risk score and tumor immune infiltration, with higher risk score accompanied wit

SUBMITTER: Dang Q 

PROVIDER: S-EPMC8578893 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature