The Host Response to Viral Infections Reveals Common and Virus-Specific Signatures in the Peripheral Blood.

ABSTRACT: Viruses cause a wide spectrum of clinical disease, the majority being acute respiratory infections (ARI). In most cases, ARI symptoms are similar for different viruses although severity can be variable. The objective of this study was to understand the shared and unique elements of the host transcriptional response to different viral pathogens. We identified 162 subjects in the US and Sri Lanka with infections due to influenza, enterovirus/rhinovirus, human metapneumovirus, dengue virus, cytomegalovirus, Epstein Barr Virus, or adenovirus. Our dataset allowed us to identify common pathways at the molecular level as well as virus-specific differences in the host immune response. Conserved elements of the host response to these viral infections highlighted the importance of interferon pathway

SUBMITTER: Tsalik EL 

PROVIDER: S-EPMC8578928 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature