Pleural Pressure Targeted Positive Airway Pressure Improves Cardiopulmonary Function in Spontaneously Breathing Patients With Obesity.

ABSTRACT:

Background

Increased pleural pressure affects the mechanics of breathing of people with class III obesity (BMI > 40 kg/m²).

Research question

What are the acute effects of CPAP titrated to match pleural pressure on cardiopulmonary function in spontaneously breathing patients with class III obesity?

Study design and methods

We enrolled six participants with BMI within normal range (control participants, group I) and 12 patients with class III obesity (group II) divided into subgroups: IIa, BMI of 40 to 50 kg/m²; and IIb, BMI of ≥ 50 kg/m². The study was performed in two phases: in phase 1, participants were supine and breathing spontaneously at atmospheric pressure, and in phase 2, participants were supine and breathing with CPAP titrat

SUBMITTER: Florio G 

PROVIDER: S-EPMC8579318 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature