Associations of FKBP5 polymorphisms and methylation and parenting style with depressive symptoms among Chinese adolescents.

ABSTRACT:

Background

Genetic factors may interplay with environmental stressors to contribute to risks of depressive symptoms. This study aimed to investigate the association of FKBP5 polymorphisms and DNA methylation with depressive symptoms among Chinese adolescents, considering the role of parenting style.

Methods

This study used a nested case-control study design based on a cohort study, and the case (n = 120) and control groups (n = 118) were matched with age. Depressive symptoms, parenting style, and other demographics were measured. Fourteen potential polymorphisms and one promoter region in the FKBP5 gene were selected for genotyping and methylation analysis.

Results

In the adjusted models, a significant association between FKBP5 rs7757037 and depressive symptoms was fo

SUBMITTER: Guo L 

PROVIDER: S-EPMC8579536 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature