Mammary collagen architecture and its association with mammographic density and lesion severity among women undergoing image-guided breast biopsy.

ABSTRACT:

Background

Elevated mammographic breast density is a strong breast cancer risk factor with poorly understood etiology. Increased deposition of collagen, one of the main fibrous proteins present in breast stroma, has been associated with increased mammographic density. Collagen fiber architecture has been linked to poor outcomes in breast cancer. However, relationships of quantitative collagen fiber features assessed in diagnostic biopsies with mammographic density and lesion severity are not well-established.

Methods

Clinically indicated breast biopsies from 65 in situ or invasive breast cancer cases and 73 frequency matched-controls with a benign biopsy result were used to measure collagen fiber features (length, straightness, width, alignment, orientation and density (fibe

SUBMITTER: Bodelon C 

PROVIDER: S-EPMC8579610 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature