Long-term outcomes of busulfan plus melphalan-based versus melphalan 200 mg/m² conditioning regimens for autologous hematopoietic stem cell transplantation in patients with multiple myeloma: a systematic review and meta-analysis.

ABSTRACT:

Background

High-dose melphalan (HDMEL, 200 mg/m²) is considered as the standard conditioning regimen for autologous hematopoietic stem cell transplantation (auto-HSCT) in multiple myeloma (MM). However, whether the combination of melphalan with busulfan (BUMEL) conditioning outperforms HDMEL remains controversy. Accordingly, a systematic review and meta-analysis was carried out to compare the outcomes of HDMEL and BUMEL-based conditioning regimens in newly diagnosed MM patients having undergone auto-HSCT.

Methods

A systematic literature search was conducted in PubMed, Embase and Cochrane Library database until July 31, 2021, to identify all eligible studies comparing progression-free survival (PFS), overall survival (OS), optimal treatment response after auto-HSCT

SUBMITTER: Gao F 

PROVIDER: S-EPMC8579671 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature