Longitudinal analysis of FcRL5 expression and clonal relationships among classical and atypical memory B cells following malaria.

ABSTRACT:

Background

Chronic and frequently recurring infectious diseases, such as malaria, are associated with expanded populations of atypical memory B cells (MBCs). These cells are different from classical MBCs by the lack of surface markers CD21 and CD27 and increased expression of inhibitory receptors, such as FcRL5. While the phenotype and conditions leading to neogenesis of atypical MBCs in malaria-experienced individuals have been studied extensively, the origin of these cells remains equivocal. Functional similarities between FcRL5⁺ atypical MBCs and FcRL5⁺ classical MBCs have been reported, suggesting that these cells may be developmentally related.

Methods

Here, a longitudinal analysis of FcRL5 expression in various B cell subsets was performed in two

SUBMITTER: Gonzales SJ 

PROVIDER: S-EPMC8579674 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature