Steroid treatment in patients with acute respiratory distress syndrome: a systematic review and network meta-analysis.

ABSTRACT:

Purpose

Although the most recent systematic review and meta-analyses on acute respiratory distress syndrome (ARDS) have shown that the use of steroids decreases mortality in adult patients, its benefits and risks may differ depending on the type and dosage of the steroid. Therefore, we conducted a network meta-analysis (NMA) to compare the differences in the efficacy among different doses and types of steroids.

Methods

We searched MEDLINE, CENTRAL, ICHUSHI, ClinicalTrials.gov, and WHO ICTRP databases from the earliest records to March 2021 for randomized control trials, which compared steroids with placebo or conventional therapy for ARDS. Using the random-effects model, we compared various categories of steroids (high-dose methylprednisolone, low-dose methylprednisolone, hy

SUBMITTER: Yoshihiro S 

PROVIDER: S-EPMC8579727 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature