Role of the Filifactor alocis Hypothetical Protein FA519 in Oxidative Stress Resistance.

ABSTRACT: In the periodontal pocket, there is a direct correlation between environmental conditions, the dynamic oral microbial flora, and disease. The relative abundance of several newly recognized microbial species in the oral microenvironment has raised questions on their impact on disease development. One such organism, Filifactor alocis, is significant to the pathogenic biofilm structure. Moreover, its pathogenic characteristics are highlighted by its ability to survive in the oxidative-stress microenvironment of the periodontal pocket and alter the microbial community dynamics. There is a gap in our understanding of its mechanism(s) of oxidative stress resistance and impact on pathogenicity. Several proteins, including HMPRFF0389-00519 (FA519), were observed in high abundance in F. alocis duri

SUBMITTER: Aja E 

PROVIDER: S-EPMC8579941 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature