PCSK9 Activity Is Potentiated Through HDL Binding.

ABSTRACT:

Rationale

Proprotein convertase subtilisin/kexin type 9 (PCSK9) circulates in a free and lipoprotein-bound form, yet the functional consequence of the association between PCSK9 and high-density lipoprotein (HDL) remains unexplored.

Objective

This study sought to interrogate the novel relationship between PCSK9 and HDL in humans.

Methods and results

Comparing lipoprotein and apolipoprotein profiles by nuclear magnetic resonance and targeted mass spectrometry measurements with PCSK9 levels in the community-based Bruneck (n=656) study revealed a positive association of plasma PCSK9 with small HDL, alongside a highly significant positive correlation between plasma levels of PCSK9 and apolipoprotein-C3, an inhibitor of lipoprotein lipase. The latter association was replica

SUBMITTER: Burnap SA 

PROVIDER: S-EPMC8579991 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature