Association between ADRB2 regulatory region polymorphisms and susceptibility to childhood asthma.

ABSTRACT:

Objectives

To study the association of β2-drenergic receptor (ADRB2) regulatory region single nucleotides polymorphism (SNP)/haplotypes at rs11168070, rs17108803, rs2053044, rs12654778, rs11959427, and rs2895795 loci with childhood asthma.

Methods

A total of 143 children with asthma who attended the hospital from October 2016 to October 2020 were enrolled as the asthma group, among whom 61 children had mild symptoms (mild group) and 82 children had moderate-to-severe symptoms (moderate-to-severe group). A total of 137 healthy children were enrolled as the control group. Peripheral venous blood samples were collected from the two groups. The SNaPshot SNP technique was used to analyze the SNP and haplotypes of the ADRB2 regulatory region at rs11168070, rs17108803

SUBMITTER: Cai MX 

PROVIDER: S-EPMC8580024 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature