Prevalence of Y chromosome microdeletion in azoospermia factor subregions among infertile men from West Bengal, India.

ABSTRACT:

Background

Etiology of male infertility is intriguing and Y chromosome microdeletion within azoospermia factor (AZF) sub-regions is considered major cause. We conducted a screening for Y chromosome microdeletion in an infertile male cohort from West Bengal, India to characterize Y chromosome microdeletion among infertile men.

Methods

We recruited case subjects that were categorized on the basis of sperm count as azoospermia (N = 63), severe oligozoospermia (N = 38), and oligozoospermia (N = 17) and compared them with age, demography, and ethnicity matched healthy proven fertile control males (N = 84). Sequence Tagged Site makers and polymerase chain reaction based profiling of Y chromosome was done for AZF region and SRY for cases and controls.

Results

We scored 16.1%

SUBMITTER: Dutta S 

PROVIDER: S-EPMC8580071 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature