Macrophage-targeted nanomedicine for the diagnosis and treatment of atherosclerosis.

ABSTRACT: Nanotechnology could improve our understanding of the pathophysiology of atherosclerosis and contribute to the development of novel diagnostic and therapeutic strategies to further reduce the risk of cardiovascular disease. Macrophages have key roles in atherosclerosis progression and, therefore, macrophage-associated pathological processes are important targets for both diagnostic imaging and novel therapies for atherosclerosis. In this Review, we highlight efforts in the past two decades to develop imaging techniques and to therapeutically manipulate macrophages in atherosclerotic plaques with the use of rationally designed nanoparticles. We review the latest progress in nanoparticle-based imaging modalities that can specifically target macrophages. Using novel molecular imaging technolo

SUBMITTER: Chen W 

PROVIDER: S-EPMC8580169 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature