Excreted Trypanosoma brucei proteins inhibit Plasmodium hepatic infection.

ABSTRACT: Malaria, a disease caused by Plasmodium parasites, remains a major threat to public health globally. It is the most common disease in patients with sleeping sickness, another parasitic illness, caused by Trypanosoma brucei. We have previously shown that a T. brucei infection impairs a secondary P. berghei liver infection and decreases malaria severity in mice. However, whether this effect requires an active trypanosome infection remained unknown. Here, we show that Plasmodium liver infection can also be inhibited by the serum of a mouse previously infected by T. brucei and by total protein lysates of this kinetoplastid. Biochemical characterisation showed that the anti-Plasmodium activity of the total T. brucei lysates depends on its protein fraction, but is independent of the abundant var

SUBMITTER: Temporao A 

PROVIDER: S-EPMC8580256 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature